Researchers continue to explore the interaction of nutrients and the gastrointestinal tract, particularly the microbes that make up the microbiome. While some research was conducted to determine if fructose caused changes to the microbiome that could lead to obesity, no scientific evidence has found a component of the diet, such as fructose, to be responsible for obesity or metabolic disorders. More recently some dietitians have been suggesting low-FODMAP diets for managing irritable bowel syndrome. FODMAP diets are low in Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols and include foods that are low in fructose but not fructose-free. To date there is limited data regarding the effectiveness of this diet in reducing symptoms. However, some healthcare providers may consider this dietary approach for some patients. It is important to consider the risk of nutrient deficiencies in this diet and that reintroduction of foods should be planned for these patients.
Research Study Summaries
High intake of dietary fructose in overweight/obese teenagers associated with depletion of Eubacterium and Streptococcus in gut microbiome
Gut Microbes. 2019 Apr 16:1-8. doi: 10.1080/19490976.2019.1592420. Jones RB, Alderette TL, Kim JS, et al. Download Research Study PDF Objective To determine how dietary macronutrients are associated with the relative abundance of gut bacteria in healthy adolescents. Background A western high fat, high carbohydrate diet has been shown to be associated with decreased gut bacterial […]
Short-Term Isocaloric Intake of a Fructose- but not Glucose-Rich Diet Affects Bacterial Endotoxin Concentrations and Markers of Metabolic Health in Normal Weight Healthy Subjects
Mol Nutr Food Res, 2019; //doi: 10.1002/mnfr.201800868 Nier A, Brandt A, Rajcic D, et al. Download Research Study PDF Objective To determine if an isocaloric exchange of complex carbohydrates with fructose or glucose affects surrogate markers of liver health and vascular endothelial function in healthy normal weight young male and female adults. If so, the […]
Gut microbial adaptation to dietary consumption of fructose, artificial sweeteners and sugar alcohols: implications for host-microbe interactions contributing to obesity
Calorie Control Council Comments Payne AN, Chassard C, Lacroix C. Gut microbial adaptation to dietary consumption of fructose, artificial sweeteners and sugar alcohols: implications for host-microbe interactions contributing to obesity. Obes Rev. 2012 Sep. A recent review by Payne et al. (1) proposes the hypothesis that sugar compounds—particularly free fructose—contribute to obesity by conditioning gut […]
An article “Gut Microbial Adaptation to Dietary Consumption of Fructose Artificial Sweeteners and Sugar Alcohols: Implications for host-microbe interactions contributing to obesity,” fails to show that fructose and low-calorie sweeteners contribute to obesity.