Endocrinol Diabetes Nutr. 2019. //doi.org/10.1016/j.endinu.2018.12.008 —
Mohsenpour MA, Kaseb F, Nazemian R, et al. —
examine the effect of a new mixture of sugars and sugar alcohol on the
postprandial blood glucose levels and its possible gastrointestinal (GI)
adverse reactions in human adults.
- Various compounds such as sugars, sugar
alcohols and non-sugar compounds (stevia, xylitol, and aspartame) have
been introduced to induce the sweet taste in food industry.
- Lacritose, a new sweetener, was recently introduced
by mixing the following four sugars: lactose, fructose, sucrose, and
- Although previous studies have shown sugars can
interact each other during absorption in the intestine and slowdown or
increase each other’s absorption, further research is needed regarding the
glycemic response and possible gastrointestinal adverse reactions associated
- Forty participants, including 20 diabetic
patients and 20 healthy individuals, ages 20-60 (mean age = 40) were
enrolled between February and October of2016.
- A double-blind, three way randomized cross-over
clinical trial was conducted in which each participant served as his/her
own control. After fasting overnight for at least 10 hours, participants
were randomly given 300ml servings of three beverages containing 50g
glucose, sucrose and lacritose. Blood samples were collected before and
afterwards every 30 minutes for up to 2 hours.
- Demographic data was collected and
anthropometric assessments were conducted on each intervention day. A gastrointestinal reaction questionnaire,
which assessed pain in the stomach and abdomen, heartburn, reflux,
appetite, etc., was completed for each participant one day after the
intervention day by a trained nutritionist on the phone.
- Mean blood glucose was significantly lower
during consumptions of lacritose compared to sucrose and glucose (mean±
standard error (SE) for lacritose: 114.9 ± 2.5, glucose:154.8 ± 5.0,
sucrose: 134.3 ± 4.0, P-value <0.001).
Also the increasing of blood glucose at different times was
significantly different between the three drinks.
- In both participants with diabetes mellitus and
healthy subjects, blood glucose was significantly lower after ingesting
lacritose when compared to other beverages, after adjustment for BMI,
gender, age and rolling method (P-value <0.05).
- The number of participants reporting abdominal
pain, epigastric pain and also nausea after ingestion of the test
beverages were higher when they ingested lacritose. However the difference between beverages
were not statistically significant for abdominal pain (P-value = 0.165),
epigastric pain (P-value = 0.097) and nausea (P-value = 0.717).
- Blood glucose levels were significantly lower
after ingestion of one 50 g dose of lacritose, as compared to identical servings
of glucose and sucrose.
- Although lacritose contains lactose, the
gastrointestinal adverse reactions after its ingestion was not
significantly different compared to glucose and sucrose.
- Further studies with more study participants
examining the long-term effects of lacritose on appetite, body weight and
other metabolic markers of long-term glucose control are recommended.
Points to Consider:
- The present study included a sample of only 40
participants and did not assess the effect of lacritose on appetite, insulin
response and long-term outcomes.
- The long-term effect of lacritose on overall
health are unknown and given its relatively high amount of lactose and
erythritol, they may be adverse reactions associated with long-term use.