Heart Health

Scientists have been studying the relationship between obesity and metabolic risk factors for decades. One specific relationship being evaluated is the relationship between sugar consumption and cardiovascular disease.

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Research Study Summaries

Study Summary of “Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity”

For your information, a study entitled “Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity” was recently published in the Journal of Internal Medicine. The purpose of this study by Taskinen et al. was to determine the effects of fructose on liver fat development, body composition, dietary […]

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Early Life Fructose Exposure and Its Implications for Long-Term Cardiometabolic Health in Offspring

A review was recently published in Nutrients which examined the relationship between early life exposure to fructose and cardiometabolic outcomes in offspring. Reviewers cited a number studies which associated fructose intake with various health outcomes such as insulin resistance, elevated low density lipoprotein cholesterol, elevated triglycerides, obesity, type 2 diabetes, cardiovascular disease, non-fatal myocardial infarction, and […]

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High Intake of Fructose Does Not Differentially Affect Health as Compared to Lower Intake Levels

According to a recent study, a high consumption level of fructose does not lead to high cholesterol or high blood pressure.

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Singling out fructose in liver and heart disease is not scientifically justified

A recent article published in Harvard Heart Letter recommended that readers cut back on fructose.

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Effect of Fructose on Blood Pressure

A Systematic Review and Meta-Analysis of Controlled Feeding Trials

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Calorie Control Council Response to Brown et al

Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure

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Calorie Control Council Response to Cox et al

Circulating Concentrations of Monocyte Chemoattractant Protein-1, Plasminogen Activator Inhibitor-1, and Soluble Leukocyte Adhesion Molecule-1 in Overweight/Obese Men and Women Consuming Fructose- or Glucose-Sweetened Beverages for 10 Weeks

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Calorie Control Council Response to Jalal et al.

Increased Fructose Associates with Elevated Blood Pressure

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Fructose as cause of metabolic syndrome is poorly supported

In a recent paper, Perez-Pozo et al. concluded that high doses of fructose raise blood pressure and cause features of metabolic syndrome, and that fructose may therefore have a role in the current epidemics of obesity and diabetes.

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Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents

The conclusion by Nguyen et al that higher sugar-sweetened beverage consumption (as proxy for dietary fructose) may affect cardiovascular risk factors like serum uric acid and blood pressure lacks significance for three reasons.

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Postulated Fructose Influence on Myocardial Infarction is Unconvincing

In a recent paper, Gul et al. suggested that increased fructose concentration induces the aging process and myocardial infarction through production of advanced glycation endproducts (AGEs), however, their supporting evidence is unconvincing.

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Methodological problems invalidate sugars differences

In a recent paper, Le et al. reported finding differences between the two most commonly used sweeteners in the US, concluding that “compared with sucrose, HFCS [high fructose corn syrup] leads to greater fructose systemic exposure and significantly different acute metabolic effects.” Evidence in support of this conclusion was unconvincing, however, due to significant deficiencies in the experimental design.

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