Scientists have been studying the relationship between obesity and metabolic risk factors for decades. One specific relationship being evaluated is the relationship between sugar consumption and cardiovascular disease.
Research Study Summaries
J Physiol 597.14 (2019) pp 3561–3571 Luc Tappy and Robin Rosset Download Research Study PDF Objective To draft an overview of fructose metabolism, focusing on its potential detrimental effects for health on one hand, and on its potential beneficial effects during exercise on the other, and to propose a simple model to account for the […]
Short-Term Isocaloric Intake of a Fructose- but not Glucose-Rich Diet Affects Bacterial Endotoxin Concentrations and Markers of Metabolic Health in Normal Weight Healthy Subjects
Mol Nutr Food Res, 2019; //doi: 10.1002/mnfr.201800868 Nier A, Brandt A, Rajcic D, et al. Download Research Study PDF Objective To determine if an isocaloric exchange of complex carbohydrates with fructose or glucose affects surrogate markers of liver health and vascular endothelial function in healthy normal weight young male and female adults. If so, the […]
J Clin Nutr 2019; //doi.org/10.1038/s41430-019-0407-z — Philip Prinz Eur — Download Research Study PDF — Objective: To conduct a review highlighting current literature to discuss the question of whether dietary sugars per se have an unfavorable health effect or if it is just the amount of calories that matters in the development of noncommunicable diseases […]
Study Summary of “Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity”
For your information, a study entitled “Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity” was recently published in the Journal of Internal Medicine. The purpose of this study by Taskinen et al. was to determine the effects of fructose on liver fat development, body composition, dietary […]
A review was recently published in Nutrients which examined the relationship between early life exposure to fructose and cardiometabolic outcomes in offspring. Reviewers cited a number studies which associated fructose intake with various health outcomes such as insulin resistance, elevated low density lipoprotein cholesterol, elevated triglycerides, obesity, type 2 diabetes, cardiovascular disease, non-fatal myocardial infarction, and […]
According to a recent study, a high consumption level of fructose does not lead to high cholesterol or high blood pressure.
A recent article published in Harvard Heart Letter recommended that readers cut back on fructose.
A Systematic Review and Meta-Analysis of Controlled Feeding Trials
Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure
Circulating Concentrations of Monocyte Chemoattractant Protein-1, Plasminogen Activator Inhibitor-1, and Soluble Leukocyte Adhesion Molecule-1 in Overweight/Obese Men and Women Consuming Fructose- or Glucose-Sweetened Beverages for 10 Weeks
Increased Fructose Associates with Elevated Blood Pressure
In a recent paper, Perez-Pozo et al. concluded that high doses of fructose raise blood pressure and cause features of metabolic syndrome, and that fructose may therefore have a role in the current epidemics of obesity and diabetes.
The conclusion by Nguyen et al that higher sugar-sweetened beverage consumption (as proxy for dietary fructose) may affect cardiovascular risk factors like serum uric acid and blood pressure lacks significance for three reasons.
In a recent paper, Gul et al. suggested that increased fructose concentration induces the aging process and myocardial infarction through production of advanced glycation endproducts (AGEs), however, their supporting evidence is unconvincing.
In a recent paper, Le et al. reported finding differences between the two most commonly used sweeteners in the US, concluding that “compared with sucrose, HFCS [high fructose corn syrup] leads to greater fructose systemic exposure and significantly different acute metabolic effects.” Evidence in support of this conclusion was unconvincing, however, due to significant deficiencies in the experimental design.