Many published animal studies feed animals with excessive fructose, in some cases as much as 60% of total daily calories, to determine possible pathways that may be involved in kidney disease. It is important to note this amount of fructose far exceeds what people normally consume. Additionally, dietary fructose is typically not consumed in an isolated form but rather accompanied by other sugars like glucose.

Dietary fructose consumption does not contribute to poor kidney health outcomes when consumed in normal amounts in the human diet. However, it is important to note that obesity and diabetes can be inter-related in individuals with chronic kidney disease and metabolic syndrome.