Brain & Cognition

Observational Findings Linking Intake of Sugar Containing Beverage Do Not Accurately Represent Americans’ Risk For Preclinical Alzheimer’s Disease

While a recent study alleges estimated intake of sugar containing beverages is associated with markers of preclinical Alzheimer’s disease, the observational nature of the study and other important limitations temper any significance of the findings. In the study, “Sugary beverage intake and preclinical Alzheimer’s disease in the community”, Pase et al., analyzed data from a […]

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“The human brain produces fructose from glucose” Summary and Points of Consideration

A recent study entitled “The human brain produces fructose from glucose” published in JCI Insight sought to examine whether peripheral hyperglycemia can drive intracerebral production of fructose through the polyol pathway [glucose –(aldose reductase)à sorbitol –(sorbitol dehydrogenase)à fructose] in an exploratory study. Researchers at Yale selected 4 male and 4 female participants (mean: age 28.8, […]

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Increased fructose intake as a risk factor for dementia. J Gerontol A Biol Sci Med Sci. 2010

In a recent paper, Stephan et al. speculated that high fructose intake is a risk factor for dementia and that increasing consumption of fructose in the U.S. population could lead to greater dementia risk. Their premise is weakened, however, by outdated references to fructose intake and functional properties, and by a reliance on supporting evidence gathered under extreme experimental conditions unrelated to typical human fructose exposure.

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