High intake of dietary fructose in overweight/obese teenagers associated with depletion of Eubacterium and Streptococcus in gut microbiome

Gut Microbes. 2019 Apr 16:1-8. doi:

Jones RB, Alderette TL, Kim JS, et al.

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  • To
    determine how dietary macronutrients are associated with the relative
    abundance of gut bacteria in healthy adolescents.


  • A western high fat, high carbohydrate diet has
    been shown to be associated with decreased gut bacterial diversity and
    reductions in beneficial bacteria.
  • This gut bacteria dysbiosis could develop in
    early life and contribute to chronic disease risk such as obesity, type 2
    diabetes and non-alcoholic fatty liver disease.


  • Fifty-two
    obese participants, ages 12–19 years and primarily of Hispanic descent,
    were recruited for this study.  Each
    participant provided fecal samples for 16S rRNA gene sequencing.
  • Dietary
    macronutrients were assessed using 24-hour diet recalls and body
    composition was assessed using DEXA.
  • General
    regression models assuming a negative binomial distribution were used to
    examine the associations between gut bacteria and dietary fiber, saturated
    fat, unsaturated fats, protein, added sugar, total sugar and free fructose
    after adjusting for age, gender, race/ethnicity, body fat percentage,
    study and caloric intake.


  • Eubacterium and Streptococcus were inversely associated with dietary fructose
  • There were no other significant associations
    between abundances of gut microbes and other dietary macronutrients,
    including fiber, fat, protein, total sugar or added sugar.


  • High
    dietary fructose was associated with lower abundance of the beneficial
    microbes Eubacterium and Streptococcus, which are involved
    with carbohydrate metabolism.
  • Additional
    research is needed in this area.

to Consider:

  • Given the small size, age and ethnicity of the sample, the
    generalizability of these results is limited.
  • Dietary Intake information was self-reported and collected
    via 24-hour diet recalls. Not only does this information not reflect overall
    dietary habits, this method of collection is subject to recall and reporting