Does fructose lead to increased uric acid production?

There is no consistent evidence to show that fructose consumption can lead to elevated serum uric acid levels. While some studies have speculated about a potential association between fructose consumption and elevated serum uric acid levels, those experiments have used extreme diets that do not resemble real world human exposures; and, thus, have limited relevance.

Systematic reviews and meta-analyses on the subject have found that controlled feeding of fructose does not lead to increased uric acid production. A systematic review by Wang et al. (2012) found that, in an isocaloric setting, “there was no effect of fructose substitution for other carbohydrates on uric acid concentrations.” A review of US National Health and Nutrition Examination Survey (NHANES) results by Sun et al. (2010) found that increased dietary fructose intake was not associated with increased risk of elevated uric acid production. Further, the authors found that those in the highest fructose intake group were more likely to have lower levels of uric acid production (Sun et al., 2010).