Body Weight

Fructose Consumption Contributes to Hyperinsulinemia in Adolescents With Obesity Through a GLP-1–Mediated Mechanism

By Body Weight, Diabetes

J Clin Endocrinol Metab. 2019 Aug 1;104(8):3481-3490. doi: 10.1210/jc.2019-00161 Galderisi A, Giannini C, van Name M, et al. Download Research Study PDF Objective To test the hypothesis that that the ingestion of glucose and fructose may differentially stimulate GLP-1 and insulin response in lean adolescents and adolescents with obesity. Background The consumption of high-fructose beverages […]

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Fructose and metabolic health: governed by hepatic glycogen status?

By Body Weight, Diabetes

J Physiol 597.14 (2019) pp 3573–3585 Hengist A, Koumanov F and Gonzalez JT. Download Research Study PDF Objective To present the hypothesis that hepatic glycogen stores may regulate metabolic responses to fructose ingestion and could therefore be a target to prevent or mitigate the negative metabolic effects of fructose intake. Background Fructose is a commonly […]

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Early Life Sugar Consumption Affects the Rat Microbiome Independently of Obesity

By Body Weight

A recent study published in The Journal of Nutrition utilized a rodent model to assess the impact of early-life added sugar consumption on the composition of the gut microbiome, caloric intake, and weight gain. Researchers divided 42 juvenile male Sprague-Dawley rats (post-natal day 26) into 4 groups that were maintained on identical diets with varying […]

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Sugar Consumption, Metabolic Disease and Obesity: The State of the Controversy

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A review article published in Clinical Reviews in Clinical Laboratory Sciences discusses the current scientific evidence which fosters an environment of controversy about the health effects of sugar consumption.  The reviewers evaluated research which examined both direct and indirect effects of added sugars on the development of metabolic disease which, for the case of this […]

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No Differential Effect of Beverages Sweetened with Fructose, High-Fructose Corn Syrup, or Glucose on Systemic or Adipose Tissue Inflammation in Normal-Weight to Obese Adults

By Body Weight

A new study, published in the American Journal of Clinical Nutrition, reports that consumption of beverages sweetened with glucose, fructose, or high-fructose corn syrup (HCFS) do not promote inflammation or gut permeability. Researchers have hypothesized that systemic inflammation increases risk for development of insulin resistance, type 2 diabetes, and cardiovascular disease in obese individuals. Similarly, […]

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